Methotrexate is a drug used for many health issues. It helps treat cancer, rheumatoid arthritis, and psoriasis. People take it in different forms. Some take pills, while others get it through an injection. But what about its effects on blood sugar? Does it cause low blood sugar? Let’s explore this topic in detail.
Understanding Methotrexate
Methotrexate works by blocking certain processes in the body. It helps slow down cell growth. This is useful in treating cancer. It also reduces inflammation in conditions like arthritis. Methotrexate is effective but comes with side effects. These can affect how the body works.

Credit: www.cdc.gov
What is Low Blood Sugar?
Low blood sugar is when your body has too little glucose. Glucose is a type of sugar that gives energy. When blood sugar is low, you may feel weak or dizzy. Other symptoms include:
- Shakiness
- Heart palpitations
- Cold sweats
- Confusion
- Headaches
Severe low blood sugar can be dangerous. It can lead to fainting or seizures. It is essential to keep blood sugar levels stable.
Does Methotrexate Cause Low Blood Sugar?
Research shows mixed results. Some studies suggest methotrexate can lower blood sugar. Others do not find a direct link. Methotrexate may cause weight gain and increase blood sugar levels in some people. This can make it tricky to understand its effects.
Some medications can cause low blood sugar. For example:
- Insulin
- Beta-blockers
- Glinides
- Indomethacin
But methotrexate is not typically known for this. Most people do not experience low blood sugar from taking methotrexate.
How Methotrexate Affects Blood Sugar
Methotrexate may influence how the body uses glucose. Some studies suggest it helps the body take in glucose better. This might help some people manage their blood sugar. However, it may not be the case for everyone.
Doctors caution about using methotrexate with other drugs. Some combinations can lead to low blood sugar. Always tell your doctor about other medications you take.
Side Effects of Methotrexate
Like any medication, methotrexate has side effects. These can include:
- Fatigue
- Nausea
- Hair loss
- Skin rashes
- Changes in liver function
Some people also experience changes in blood counts. Methotrexate can lower white and red blood cell counts. This can lead to infections or bruising. If you notice unusual symptoms, contact your doctor right away.

Credit: www.rheumatologyadvisor.com
Managing Blood Sugar Levels on Methotrexate
If you take methotrexate, monitor your blood sugar. Here are some tips:
- Check your blood sugar regularly.
- Keep a record of your readings.
- Eat balanced meals with enough carbs.
- Stay hydrated.
- Exercise regularly.
These actions can help keep your blood sugar stable. If you notice any changes, talk to your doctor.
Consulting Your Doctor
Always consult your doctor before making changes. This includes changing your diet or exercise routine. Your doctor can provide valuable advice. They can help you understand the risks and benefits of methotrexate.
Frequently Asked Questions
What Medications Cause Low Blood Sugar?
Medications that can cause low blood sugar include insulin, sulfonylureas, beta-blockers, glinides, and indomethacin. Overdose of certain heart arrhythmia drugs like quinidine may also lead to low blood sugar levels. Always consult a healthcare professional before making any medication changes.
What Are Red Flags For Methotrexate Side Effects?
Red flags for methotrexate side effects include skin blistering, persistent cough, diarrhea, severe itching, and joint pain. Watch for red, irritated eyes, skin lesions, and sore throat. Seek immediate medical attention for any of these symptoms to ensure safety and proper care.
Does Methotrexate Cause A Low Blood Count?
Yes, methotrexate can cause a low blood count. It may decrease white blood cells, red blood cells, and platelets, particularly at higher doses. This reduction can heighten the risk of infections and bleeding. Regular blood tests are essential to monitor these effects while on the medication.
What Foods Cannot Be Eaten When On Methotrexate?
While on methotrexate, avoid unpasteurized milk and soft cheeses to reduce infection risk. Limit caffeine intake from coffee, tea, cola, energy drinks, and chocolate. No specific foods must be completely avoided, but caution is advised. Always consult your healthcare provider for personalized advice.
Conclusion
In conclusion, methotrexate does not commonly cause low blood sugar. However, it can affect how the body uses glucose. Each person’s reaction to the drug may vary. Some may experience weight gain or other side effects. If you take methotrexate, monitor your health closely. Always communicate with your healthcare provider. They are your best resource.
Understanding how medications work is important. Always be informed about what you take. Knowledge is power when managing your health.
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