Methotrexate is a medicine. It is used to treat many health problems. Some people use it for rheumatoid arthritis. Others may use it for psoriasis. You might wonder, “Does methotrexate raise blood sugar?” This article will help you understand this question.
What is Methotrexate?
Methotrexate is an anti-inflammatory drug. It helps reduce swelling and pain. It works by lowering the immune system activity. This is useful for autoimmune diseases. Autoimmune diseases cause the body to attack itself.
How Does Methotrexate Affect Blood Sugar?
Most studies show that methotrexate does not raise blood sugar levels. In fact, it may help improve insulin sensitivity. Insulin sensitivity is how well your body uses insulin. Insulin helps control blood sugar levels.
Benefits Of Methotrexate
Methotrexate can offer several benefits:
- Increase insulin sensitivity
- Reduce inflammation
- Promote fat breakdown
These benefits can improve glucose uptake. Glucose uptake is how your body uses sugar. A better glucose uptake helps keep blood sugar stable.
Can Methotrexate Raise Blood Sugar in Some Cases?
In rare situations, methotrexate can raise blood sugar levels. This is more likely if you have diabetes. People with kidney problems might also see changes. High doses of methotrexate can cause issues.
How To Know If Your Blood Sugar Changes
If you take methotrexate, watch your blood sugar. If you notice changes, talk to your doctor. They can help monitor your health. Your doctor might adjust your treatment plan.
Foods to Avoid While Taking Methotrexate
There are no specific foods to avoid with methotrexate. However, some foods might be better to stay away from:
- Unpasteurized milk
- Soft cheeses
- High caffeine drinks
These foods can increase infection risk. Methotrexate can lower your ability to fight infections.

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Common Side Effects of Methotrexate
Like any medicine, methotrexate has side effects. Here are some common side effects:
- Nausea
- Fatigue
- Headaches
If you experience severe side effects, contact your doctor. They can provide support and advice.

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Frequently Asked Questions
How Does Methotrexate Affect Blood Sugar?
Methotrexate generally does not raise blood sugar levels. It may even enhance insulin sensitivity and promote glucose uptake. In rare cases, especially in diabetics or those with kidney issues, it might cause slight increases in blood sugar. Always consult a doctor if experiencing changes in levels.
What Foods Should You Avoid While Taking Methotrexate?
Avoid unpasteurized milk and soft cheeses while taking methotrexate. Limit caffeine intake from coffee, tea, cola, energy drinks, and chocolate. These foods may hinder your immune system and overall health. Always consult your healthcare provider for personalized dietary advice.
Does Rheumatoid Arthritis Cause High Blood Sugar?
Rheumatoid arthritis itself does not directly cause high blood sugar. However, chronic inflammation can affect insulin sensitivity. Medications for rheumatoid arthritis, like corticosteroids, may raise blood sugar levels. Regular monitoring is essential for those with diabetes or at risk. Always consult a healthcare provider for personalized advice.
What Medications Raise Blood Sugar Levels?
Certain medications can raise blood sugar levels. These include antipsychotics like clozapine and olanzapine, some birth control pills, beta-blockers, thiazide diuretics, and statins. Always consult your doctor if you have concerns about medication effects on blood sugar.
Conclusion
Methotrexate is a helpful medicine for many people. It does not usually raise blood sugar levels. Most patients can take it safely.
However, if you are diabetic or have kidney issues, monitor your blood sugar. Always talk to your doctor about any concerns. They can help you manage your health effectively.
Final Thoughts
In summary, methotrexate is safe for most people. It may even help improve blood sugar control. Always follow your doctor’s advice. They know your health best.
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